Prospective Cohort Study of Childhood-Onset Stargardt Disease: Fundus Autofluorescence Imaging, Progression, Comparison with Adult-Onset Disease, and Disease Symmetry
نویسندگان
چکیده
منابع مشابه
Progression of Late-Onset Stargardt Disease.
Purpose Identification of sensitive biomarkers is essential to determine potential effects of emerging therapeutic trials for Stargardt disease. This study aimed to describe the natural history of late-onset Stargardt, and demonstrates the accuracy of retinal pigment epithelium (RPE) atrophy progression as an outcome measure. Methods We performed a retrospective cohort study collecting multic...
متن کاملQuantitative fundus autofluorescence in recessive Stargardt disease.
PURPOSE To quantify fundus autofluorescence (qAF) in patients with recessive Stargardt disease (STGD1). METHODS A total of 42 STGD1 patients (ages: 7-52 years) with at least one confirmed disease-associated ABCA4 mutation were studied. Fundus AF images (488-nm excitation) were acquired with a confocal scanning laser ophthalmoscope equipped with an internal fluorescent reference to account for...
متن کاملFine central macular dots associated with childhood-onset Stargardt Disease.
Booij JC, Baas DC, Beisekeeva J, Gorgels TG & Bergen AA (2010): The dynamic nature of Bruch’s membrane. Prog Retin Eye Res 29: 1–18. Finger RP, Charbel Issa P, Schmitz-Valckenberg S, Holz FG & Scholl HN (2011): Longterm effectiveness of intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks in pseudoxanthoma elasticum. Retina 31: 1268–1278. Gliem M, De Zeaytijd J...
متن کاملClinical and Molecular Characteristics of Childhood-Onset Stargardt Disease
PURPOSE To describe the clinical and molecular characteristics of patients with childhood-onset Stargardt disease (STGD). DESIGN Retrospective case series. PARTICIPANTS Forty-two patients who were diagnosed with STGD in childhood at a single institution between January 2001 and January 2012. METHODS A detailed history and a comprehensive ophthalmic examination were undertaken, including c...
متن کاملFundus autofluorescence patterns in stargardt disease over time.
OBJECTIVE To study the longitudinal changes in autofluorescence in Stargardt disease to reveal aspects of disease progression not previously evident. Changes in autofluorescence reflect changing fluorophore compositions of lipofuscin and melanin in retinal pigment epithelial cells, which has been hypothesized to contribute to Stargardt disease pathogenesis. METHODS We examined the temporospat...
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ژورنال
عنوان ژورنال: American Journal of Ophthalmology
سال: 2020
ISSN: 0002-9394
DOI: 10.1016/j.ajo.2019.11.008